When To Increase Your Zepbound Dose Without Regret! Watch our how to guide for doing your weightloss injections @ home! If you dont want to do them yourselves we do offer weekly apts where our providers will take care of this for you can tirzepatide make you depressed Can Zepbound (tirzepatide) be contributing to depression in an elderly male #stitch @amy this is a great topic! Does where you inject the medication change how effective it is? As long as its done on one of the subcutaneous areas mentioned and not into the muscle, then no!